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About Lexicomp Drug Interactions

lexicomp drug interactions logo

Lexicomp Drug Interactions combines medical literature and scientific understanding of drug interactions in an electronic platform, providing an efficient way to inform professionals about adverse drug events that could compromise the care of patients.

Accessing Lexicomp Through UpToDate

Accessing Lexicomp through UpToDate

Lexicomp drug information is directly integrated into UpToDate. 

Go to UpToDate and enter a drug name in the New Search box and click SearchNotice your results display the generic drug name:

Click a record to view the Lexicomp information. From the record, you will also see a link that allows you to access additional results in Lexicomp Online:


Performing a Search in Lexicomp Drug Interactions

Searching Lexicomp

In addition to having access to Lexicomp Online, you can also directly search Lexi-Interact to view drug interactions. 

Under the UpToDate search box, click Drug Interactions:

drug interactions


Enter two or more drug names to see how they interact:

lexicomp drug interactions search bar


Your results will tell you whether there is a significant interaction between the drugs.

lexicomp drug interactions results

Lexicomp Risk Ratings

Lexicomp Risk Ratings

X: Avoid Combination

D: Consider Therapy Modification

C: Monitor Therapy

B: No Needed Action

A: No Known Interaction

lexicomp risk ratings explanations

Finding Full Text in Lexicomp

Finding Full Text in Lexicomp

When viewing an article, scroll down to References, and click the PubMed ID number to see if the full text article is available:

If the article is not available or you're prompted to pay, you can install LibKey Nomad, which will instantly check to see if Gumberg can provide you with the full text. If full text is still unavailable, LibKey Nomad will help you easily request the article using ILL (ILLiad).