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UpToDate: Searching Lexi-Comp

About Lexi-Interact Online

Lexi-Interact Online combines the world's literature and scientific understanding of drug interactions with a state-of-the-art electronic platform, providing an efficient way to ensure that adverse drug events don't compromise the care of patients.

Accessing Lexi-Comp Through UpToDate

Lexi-Comp drug information is directly integrated into UpToDate. 

Go to UpToDate and enter a drug name in the New Search box then click Search:

Notice your results display the generic drug name:

Click a record to view the Lexi-Comp information. From the record, you will also see a link that allows you to access additional results in Lexi-Comp Online:

Performing a Search in Lexi-Interact Online

In addition to having access to Lexi-Comp Online, you can also directly search Lexi-Interact to view drug interactions. 

Under the UpToDate search box, click Drug Interactions:

Enter drug name in the search box then click Lookup:

Click the drug name to view record:

By default, you will see all categories of potential interactions. To change this, select the desired risk rating from the drop-down menu:

For example, selecting X from the drop-down menu will only show you drugs to avoid combining Lunesta with:

Lexi-Comp User Guides

For more information on using Lexi-Comp, try the following resource guides and tutorials.

Lexi-Comp Risk Ratings

A: No Known Interaction

B: No Needed Action

C: Monitor Therapy

D: Consider Therapy Modification

X: Avoid Combination

For more details, click here.


Ask a Librarian if you need help using Lexi-Comp.